Understanding Letrozole
Letrozole is a medication primarily used in the treatment of hormone-receptor-positive breast cancer in postmenopausal women. This drug functions as an aromatase inhibitor, which means it works by lowering estrogen levels in the body. Since some breast cancers thrive on estrogen, reducing its production helps to slow or stop the growth of these tumors.
Mechanism of Action
The description of the drug relates closely to its mechanism of action. Letrozole inhibits the aromatase enzyme, which is responsible for converting androgens into estrogens in peripheral tissues. By blocking this enzyme, letrozole effectively reduces estrogen levels, making it harder for estrogen-dependent tumors to grow.
Indications for Use
Letrozole is commonly prescribed for:
- Adjuvant treatment of hormone receptor-positive breast cancer after surgery
- Treatment of advanced breast cancer in women who are postmenopausal
- Off-label use in fertility treatments for women with polycystic ovary syndrome (PCOS)
Dosage and Administration
The typical dosage of letrozole is https://letrozole-for-sale.com/medicament/letrozol-mylan-filmtabletten-2-5mg-100-stuck/ 2.5 mg taken once daily. It can be administered with or without food, and patients are usually advised to take the medication at the same time each day to maintain even levels in the bloodstream.
Side Effects
- Hot flashes
- Joint pain or stiffness
- Fatigue
- Nausea
More serious but less common side effects can include bone density loss, which may increase the risk of fractures, and cardiovascular issues.
Contraindications and Precautions
Letrozole is not suitable for everyone. It is contraindicated in premenopausal women and those who are pregnant or breastfeeding. Care should be taken when prescribing letrozole to patients with a history of osteoporosis or other bone-related conditions.
Conclusion
In summary, the description of the drug letrozole highlights its significant role in the management of certain types of breast cancer. Its ability to lower estrogen levels makes it a crucial option in hormone-sensitive cases. However, potential users should be aware of the side effects and consult their healthcare provider to ensure proper usage and monitoring during treatment.